Scientists unravel how the immune checkpoint protein PD-L2 is regulated

In immune-related disorders, therapy often involves identifying the molecules responsible for immune dysregulation and targeting them using drugs. This type of immune therapy is also used for cancer treatment, owing to the important role that immune cells play in cancer progression. One such type of a potential therapeutic target is an “immune checkpoint” protein called PD-L2, which is specifically expressed in immune cells called dendritic cells (DCs) and macrophages.